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FDA Fighting Alzheimer’s by Targeting Trans Fat

VIDEO & IN-DEPTH ARTICLE

More than a decade ago, consumers started avoiding dementia-causing trans fats. Participation snowballed to include companies, then cities. Learn how cutting trans fat saves lives. See why a historic trans fat ban is now a heroic FDA goal.


The full-blown war on trans fat began in 1999. The FDA first proposed that manufacturers be required to declare the amount of trans fat on Nutrition Facts labels because of public health concerns. That requirement became effective in 2006.

However, there are still many processed foods made with partially hydrogenated oils (PHOs), the major dietary source of trans fat in processed food. Trans fat has been linked to an increased risk of vascular dementia, stroke and coronary heart disease, in which plaque builds up inside the arteries.

FDA Targets Trans Fat in Processed Foods - JPG 2FDA Targets Trans Fat in Processed Foods - JPG 3

A variety of processed foods—including frozen, canned and baked goods—contain trans fat. The amount per serving is listed on the Nutrition Facts label. The inclusion of partially hydrogenated oil in the list of ingredients is also an indication that trans fat is present.

The Centers for Disease Control and Prevention estimates that a further reduction of trans fat in the food supply can prevent an additional 27,000 deaths each year.

Part of the FDA’s responsibility to the public is to ensure that food in the American food supply is safe. Therefore, due to the risks associated with consuming PHOs, FDA has issued a Federal Register notice with its preliminary determination that PHOs are no longer “generally recognized as safe,” or GRAS, for short. If this preliminary determination is finalized, then PHOs would become food additives subject to premarket approval by FDA. Foods containing unapproved food additives are considered adulterated under U.S. law, meaning they cannot legally be sold.

If FDA determines that PHOs are not GRAS, it could, in effect, mean the end of artificial, industrially-produced trans fat in foods, says Dennis M. Keefe, Ph.D., director of FDA’s Office of Food Additive Safety. FDA is soliciting comments on how such an action would impact small businesses and how to ensure a smooth transition if a final determination is issued.

Trans fat wouldn’t be completely gone, Keefe notes, because it also occurs naturally in small amounts in meat and dairy products. It is also present at very low levels in other edible oils, such as fully hydrogenated oils, where it is unavoidably produced during the manufacturing process.

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About Trans Fat and PHOs

PHOs are found in many popular processed foods, like baked goods and frozen foods that time-crunched Americans use to feed their families. They have been widely used as ingredients since the 1950s to increase the shelf-life and flavor stability of foods.

But over time, various studies have linked trans fat—produced when hydrogen is added to vegetable oil to make it more solid—to artery-clogging diseases such as vascular dementia and heart disease. A 2002 report by the National Academy of Science’s Institute of Medicine found a direct correlation between intake of trans fat and increased levels of low density lipoprotein (LDL) cholesterol, commonly referred to as “bad” cholesterol. Bad cholesterol is directly tied to increased risk of dementias such as Alzheimer’s, as well as stroke and heart disease.

Keefe says that even though the FDA requirement that trans fat be listed on the Nutrition Facts label took effect in January 2006, consumers took the health warnings to heart early. They started turning away from foods with trans fat soon after publication of FDA’s final rule in 2003. Taking the lead from consumers, many processed food manufacturers followed suit and voluntarily changed their food formulations to reduce or eliminate trans fat.

However, Mical E. Honigfort, a consumer safety officer at FDA, says that trans fat can still be found in such processed foods as:

  • crackers, cookies, cakes, frozen pies and other baked goods
  • snack foods (such as microwave popcorn)
  • frozen pizza
  • vegetable shortenings and stick margarines
  • coffee creamers
  • refrigerated dough products (such as biscuits and cinnamon rolls)
  • ready-to-use frostings

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About GRAS

Under section 409 of the Federal Food, Drug, and Cosmetic Act, any substance intentionally added to food is a food additive subject to premarket approval and review by FDA, with some exceptions. The exceptions include substances “generally recognized as safe,” or GRAS, because they are generally recognized by qualified experts as safe under the conditions of intended use.

The most widely used PHOs have long been considered GRAS ingredients by the food industry. Keefe explains that companies may voluntarily notify FDA that they have determined that the use of an ingredient is GRAS, but there is no legal requirement for food manufacturers to submit a GRAS notification before going to market. If FDA ultimately determines that PHOs are not GRAS, food manufacturers would have to obtain premarket approval by FDA before adding PHOs to food.

FDA can act when it believes an ingredient is, in fact, not GRAS. And that’s what the agency’s preliminary determination is doing now with partially hydrogenated oils. A Federal Register notice was published on Nov., 7 2013 announcing the preliminary determination that PHOs are not GRAS, which includes the opening of a 60-day public comment period.

If FDA makes a final determination that PHOs are not GRAS, the agency and food industry would have to figure out a way to phase out the use of PHOs over time. To help address this concern in an appropriate manner, the Federal Register notice calls for comment on how long it would take the food industry to phase out its use of PHOs.

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What Should the Consumer Do?

In the meantime, what should the average consumer do if he or she picks up a favorite food and sees that it has trans fat on the Nutrition Facts label? The best thing to do is to consider the amounts of saturated fat, cholesterol and trans fat. Choose the product that has the lowest combined amount of these nutrients, Keefe says.

Even if a food claims on its packaging to have “0 grams trans fat,” it’s a good idea to look at the ingredients, says Honigfort. Under current regulations, companies can make that claim if the food contains less than 0.5 grams of trans fat per serving. But if there is partially hydrogenated oil listed with the ingredients, there might be a small amount of trans fat. Selecting foods with even small amounts of trans fat can add up to a significant intake.

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Raymond Neuville
Raymond Neuville
8 years ago

Completely reversed my Diabetes Type 2 in 7 months by avoiding food with Trans Fats. Not easy to identify initially because FSAs (Food Safety Authorities) do not issue lists of foods that contain Trans Fats. Build up of Trans fats over years in cell membranes progressively inhibits insulin function. Trans fats may also cause wrong cleave of the APP protein in cell walls which results in Alzheimer's Disease. I wouldn't wait around for science to prove it in the lab … avoid Trans Fats like the plague!

Raymond Neuville
Raymond Neuville
8 years ago

Completely reversed my Diabetes Type 2 in 7 months by avoiding food with Trans Fats. Not easy to identify initially because FSAs (Food Safety Authorities) do not issue lists of foods that contain Trans Fats. Build up of Trans fats over years in cell membranes progressively inhibits insulin function. Trans fats may also cause wrong cleave of the APP protein in cell walls which results in Alzheimer's Disease. I wouldn't wait around for science to prove it in the lab … avoid Trans Fats like the plague!

dr felix
dr felix
8 years ago

Thanks for the valuable information.

B. Berger

B. Berger

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Welcome

This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chaffe, the important articles & videos from each week’s river of news. With a new post on Alzheimer’s or dementia appearing on the internet every 7 minutes, the site’s focus on the best information has been a help to many over the past 15 years. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

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