VIDEO + ARTICLE:
It happens unexpectedly: a person unable to recall their past or even recognize loved ones, will suddenly wake up and exhibit surprisingly normal behavior for a short while. Experts call it terminal or paradoxical lucidity. It has been reported since antiquity, yet there are few studies. That may be about to change.
It happens unexpectedly: a person long thought lost to the ravages of dementia, unable to recall the events of their lives or even recognize those closest to them, will suddenly wake up and exhibit surprisingly normal behavior, only to pass away shortly thereafter. This phenomenon, which experts refer to as terminal or paradoxical lucidity, has been reported since antiquity, yet there have been very few scientific studies of it. That may be about to change.
LUCIDITY IN DEMENTIA STIMULATED BY MUSIC
A video clip from the film “Alive Inside:”
In an article published in the August issue of Alzheimer’s & Dementia , an interdisciplinary workgroup convened by the National Institutes of Health’s (NIH) National Institute on Aging and led by Michigan Medicine’s George A. Mashour, M.D., Ph.D., outlines what is known and unknown about paradoxical lucidity, considers its potential mechanisms, and details how a thorough scientific analysis could help shed light on the pathophysiology of dementia.
A Reversible Component of Alzheimer’s?
“We’ve assumed that advanced dementia is an irreversible neurodegenerative process with irreversible functional limitations,” says Mashour, professor in the department of anesthesiology, faculty in the neuroscience graduate program, and director of the Center for Consciousness Science. “But if the brain is able to access some sort of functional network configuration during paradoxical lucidity, even in severe dementia, this suggests a reversible component of the disease.”
Astonished Caregivers
The paper describes earlier work documenting case studies of individuals with advanced dementia, including Alzheimer’s disease, appearing to be able to communicate and recall in a seemingly normal fashion at the end of life, to the astonishment of their caregivers.
“The accumulation of anecdotal reports about paradoxical lucidity in the scientific literature prompts several important research questions,” says NIA medical officer Basil Eldadah, M.D., Ph.D.
Unexpected & Varying Lucidity
“We look forward to additional research in this area, such as better characterization of lucidity in its varying presentations, new instruments or methods to assess episodes of lucidity retrospectively or in real-time, tools to analyze speech patterns or other behavioral manifestations of lucidity, and evidence to inform decision-making challenges and opportunities prompted by unexpected lucidity.”
One precedent for investigating such events exists in the study of so-called near-death experiences. In 2013, Mashour and his collaborators at Michigan Medicine published a basic science study showing evidence of electrical brain features indicative of a conscious state following cardiac arrest.
Common Neural Network?
“We don’t know that the same thing is occurring with paradoxical lucidity, but the fact that this is usually happening around the time of death suggests there could be some common neural network mechanism,” he says.
From Mere Seconds to Several Days
Mashour admits that studying paradoxical lucidity will be a challenge, given the fleeting nature of the event. Case studies report episodes lasting from mere seconds to at most several days for a small minority of cases. The workgroup also outlines important ethical implications of this work, including the ability of vulnerable patients to participate in research and how the observation of paradoxical lucidity might change the way caregivers interact with people with dementia.
“Would research that might identify a systematically observable paradoxical lucidity provide comfort, for example, by offering loved ones a potential channel for closure, or might it induce worry if loved ones are left to wonder if a reversible cause of the dementia could have been found? We do not know the answers but these could be important research questions in their own right,” says co-first author Lori Frank, Ph.D., of the RAND Corporation and former Health and Aging Congressional fellow at the National Institute on Aging.
The workgroup hopes their paper will help raise awareness within the scientific community to advance paradoxical lucidity research, and help validate the experiences of a multitude of caregivers.
Says Mashour, “Science is now trying to be thoughtful and attentive to something that has long been reported.”
- George A. Mashour, Lori Frank, Alexander Batthyany, Ann Marie Kolanowski, Michael Nahm, Dena Schulman-Green, Bruce Greyson, Serguei Pakhomov, Jason Karlawish, Raj C. Shah. Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias. Alzheimer’s & Dementia, 2019; DOI: 10.1016/j.jalz.2019.04.002
SOURCE:
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Michigan Medicine
University of Michigan
My husband, with LBD, who had not acknowledged me or spoken a full sentence for months, said "I think I died and went to heaven." As he had not water or eaten for days it was hard to understand. He repeated it twice until I understood. He died 2 days later.
My mother, at 84yo, in late stage Alzheimer's in 1999, was nearly comatose with muscle contractures, bed-bound. Her first cousin, with whom she and her brother grew up on their family farm, visited her. My mom sat up — which she hadn't done in months — and had a 20-minute heartwarming discussion about the fun they had as kids. They talked excitedly about the games they played, picking cherries and eating them… things like that. After the cousin left, she remained lucid for another 20 minutes or so, then rapidly returned to her nearly comatose state. She died a week later. It was awesome to witness.
This will help so many families that don't understand dementia or paradoxical lucidity. My mom would break out of her fog at the strangest times throughout her battle with LBD. Some family members thought I might be exaggerating her illness and even thought she might be playing for sympathy. I've heard of "show time " but not this. Thanks
for sharing.
Dear Editor,
I am a researcher at department of medical physiology, School of Medicine, Gaziantep University. I am working on Terminal lucidity in dementia. I am now preparing an article on terminal lucidity and wish to use this video article as a supplementary material or video abstract or ı wish to use some pictures from the video in my article. Can we use for our scientific paper on severe dementia?
Best regards,
Hi Mehmet,
Please let me know specifically what you would like to use from the article and where you would be using the material. We generally approve such requests, asking you to provide attribution, and there is no charge. As for the video, it is embedded from YouTube, so you would need to ask the owner of that YouTube account for permission.
Let me know if I can be of further help. Wishing you success with your article.