Could a Harvard-developed supplement slow cognitive aging? A new product tested on mini-brains may be the most science-backed brain health formula yet.
Harvard Neuroscience Meets Everyday Brain Health
A new supplement called CogniSHIELD™ is making waves in the brain health community. Developed in collaboration with Harvard neuroscientist Dr. Rudolph E. Tanzi, the product is the first of its kind to be tested using Alzheimer’s-in-a-Dish™—a lab-grown mini-brain model that mimics age-related changes in human neurons.
This innovative approach allowed researchers to screen over 3,500 natural compounds for their ability to reduce neuroinflammation and clear beta-amyloid, two key contributors to cognitive decline. The result? A formula containing four standout ingredients: Ipriflavone, Urolithin A, Quercetin, and Fisetin.
“We developed CogniSHIELD to reflect pharmaceutical rigor, which is unique for a dietary supplement,” said George Alex, CEO of CogniSHIELD Global.
What’s Inside CogniSHIELD?
Each of the four ingredients was chosen for its unique ability to support brain health:
- Ipriflavone: A synthetic flavonoid shown to reduce inflammation and support cellular resilience.
- Urolithin A: A compound that promotes mitochondrial health and may help clear damaged cells.
- Quercetin: A plant flavonoid with antioxidant and anti-inflammatory properties.
- Fisetin: Known for its neuroprotective effects and potential to reduce senescent cells.
Together, these ingredients form a synergistic blend aimed at slowing the natural aging process of the brain.
Why This Supplement Stands Out
Unlike many over-the-counter brain boosters, CogniSHIELD was developed using rigorous scientific methods. The Alzheimer’s-in-a-Dish™ model allowed researchers to observe how each compound affected human-like brain tissue, offering a level of insight rarely seen in supplement development.
Dr. Tanzi, who co-discovered several Alzheimer’s-related genes, emphasized that supplements are just one part of a broader brain health strategy. He recommends following the SHIELD lifestyle:
- Sleep: Prioritize quality rest.
- Handle stress: Practice mindfulness and relaxation.
- Interact: Stay socially engaged.
- Exercise: Move regularly.
- Learn: Challenge your brain.
- Diet: Eat nutrient-rich foods.
What’s Next for CogniSHIELD?
A human clinical trial is expected to begin later this year to further validate the supplement’s effectiveness. In the meantime, CogniSHIELD is available for purchase at Amazon, reduced to $74.99 from $89 for a one-month supply.
What the Research Says
The development of CogniSHIELD was informed by peer-reviewed studies on neuroinflammation, mitochondrial health, and senolytics. For example:
- Fisetin has been shown to reduce markers of brain aging in preclinical models (Maher et al., Journal of Neuroscience Research).
- Urolithin A improves mitochondrial function and may enhance memory (Ryu et al., Nature Medicine).
