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Rasagiline for Parkinson’s May Also Treat Alzheimer’s

Research has shown that the Parkinson’s drug, rasagiline, could be a viable therapeutic option for people with Alzheimer’s disease. Learn about the new effort to repurpose rasagiline to treat Alzheimer’s.


NEW YORK /PRNewswire-USNewswire/ — The Alzheimer’s Drug Discovery Foundation (ADDF) announced that it raised more than $1.1 million in support of a clinical trial to test the existing drug, rasagiline, for the treatment of Alzheimer’s disease. Rasagiline is the generic name for the drug cmmonly marketed under the brand name Azilect®.

The $1.1 million was generated during the “Fund a Scientist” auction at its Eighth Annual Connoisseur’s Dinner on May 1, 2014, and awarded to Jeffrey Cummings, MD, director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada and Cleveland, Ohio. Dr. Cummings will investigate rasagiline, an FDA-approved treatment for Parkinson’s disease with the potential to be the first drug to slow the course of Alzheimer’s disease.

“Repurposing is an exciting approach because we can study drugs that are already approved by the FDA for use by physicians to treat other diseases. The results of this study may provide physicians on the frontlines of Alzheimer’s treatment with new and critical evidence to inform the treatment and care of their patients,” saidHoward Fillit, MD, executive director and chief science officer, ADDF.

Previous research has shown that rasagiline could be a viable therapeutic option for people with Alzheimer’s disease. It has already proven safe and effective in Parkinson’s disease, a neurodegenerative illness similar to Alzheimer’s disease in many ways.

“Rasagiline has neuroprotective properties, offering a novel approach to Alzheimer’s drug therapy,” says Dr. Fillit. “Currently, most Alzheimer’s drug research targets beta-amyloid, a protein found in the brain of individuals with Alzheimer’s.”

Results of Dr. Cummings’ study, which was designed in collaboration with the ADDF’s team of neuroscientists, may be available in as little as two years.

In total, the Eighth Annual Connoisseur’s Dinner raised over $3.5 million to accelerate the discovery of drugs to prevent, treat and cure Alzheimer’s disease.


About the Alzheimer’s Drug Discovery Foundation (ADDF)
The mission of the Alzheimer’s Drug Discovery Foundation (ADDF) is to accelerate the discovery of drugs to prevent, treat and cure Alzheimer’s diseases, related dementias and cognitive aging. The ADDF has granted more than $65 million to fund nearly 450 Alzheimer’s drug discovery programs in academic centers and biotechnology companies in 18 countries. In 2013, 100 percent of funds raised by the ADDF went directly to Alzheimer’s drug research and other related programs.  For more information, please visit www.AlzDiscovery.org.

SOURCE Alzheimer’s Drug Discovery Foundation

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June 8, 2018 3:21 pm

Parkinson's disease (PD) is a long-term degenerative disease of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Affected person should take parkinson's disease treatment

B. Berger

B. Berger

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