Amlodipine, an inexpensive drug approved for high blood pressure, could become the first ever treatment for vascular dementia. Vascular dementia is one of the most common forms of dementia. Find out how amlodipine can help.
Experts based at the School of Medicine, Dentistry and Biomedical Sciences at Queen’s University Belfast are testing nearly 600 people with vascular dementia in
a groundbreaking two year trial into the drug’s potential as a dementia treatment
. The researchers
, led by Professor Peter Passmore, hope to show that 10mg a day of the drug can significantly improve memory
and cognitive health. As amlodipine is already licensed and known to be safe, the treatment – which costs the NHS just £1.07 (U.S. $ 1.80)
a month – could be in use as a treatment within five to ten years.
is caused by problems with the blood supply to the brain
and affects about 150,000 people in the UK. Those with heart conditions, high cholesterol and diabetes are especially at risk
, and it can be triggered by a stroke. There are currently no available treatments
for vascular dementia yet there are fewer ongoing clinical trials for the condition
than there are for hay fever.
Amlodipine is used to treat high blood pressure, a major risk factor
for vascular dementia. It is known to enter the brain
think it might work by protecting brain cells from damage when blood supply to the brain is poor.
Professor Peter Passmore at the School of Medicine, Dentistry and Biomedical Sciences, and lead investigator, said:
is a very common disease and to date no major trial has been successful in developing an effective treatment
for this disease. We hope, using evidence from previous research
, and by trialling the drug amlodipine
we may get a step closer to improving the outcomes of patients with vascular dementia in the next decade.’
Jeremy Hughes, Chief Executive at Alzheimer’s Society said:
‘It is scandalous that despite affecting 150,000 people there are no effective treatments for vascular dementia and very few new treatments
under investigation. This groundbreaking trial could be the best hope we have to get an effective treatment in use in the next decade.
‘Developing new drugs from scratch can costs hundreds of millions and take up to twenty years but our flagship Drug Discovery programme
aims to test existing drugs in people with dementia
, fast-tracking the process and bringing new treatments
to market faster and more cheaply.
Professor Peter Weissberg, Medical Director at the BHF said:
‘The 2.3 million people living with coronary heart disease in the UK are at increased risk of developing vascular dementia
. Unfortunately, as yet, there are no effective treatments for this devastating condition.
‘Amlodipine is a widely prescribed, blood pressure lowering treatment that has shown some promising effects in vascular dementia. The BHF and Alzheimer’s Society have joined forces to fund this definitive study
. If positive, it would pave the way for an affordable treatment for vascular dementia
in the near future.’