Selenium – a mineral found in many foods – could reverse the cognitive impact of stroke and boost learning and memory in ageing brains, according to University of Queensland research.
The research was first published in Cell Metabolism.
Queensland Brain Institute (QBI) lead researcher Dr Tara Walker said studies on the impact of exercise on the ageing brain found levels of a protein key to transporting selenium in the blood were elevated by physical activity.
Findings of an earlier study — the Project FRONTIER Study — likewise indicated that selenium’s antioxidant properties could have protective effects on memory.
Can selenium replicate exercise effects?
“We’ve known for the last 20 years that exercise can create new neurons in the brain, but we didn’t really understand how,” Dr Walker said.
The research team investigated whether dietary selenium supplements could replicate the effects of exercise.
“Our models showed that selenium supplementation could increase neuron generation and improve cognition in elderly mice,” Dr Walker said.
“The levels of new neuron generation decrease rapidly in aged mice, as they do in humans. When selenium supplements were given to the mice, the production of neurons increased, reversing the cognitive deficits observed in ageing.”
Selenium’s effect on the brain after stroke
Selenium is an essential trace mineral absorbed from soil and water. It is found in foods such as grains, meat and nuts, with the highest levels found in Brazil nuts.
The scientists also tested whether selenium would have an impact on the cognitive decline sometimes experienced following stroke, which can affect people’s memory and ability to learn.
“Young mice are really good at the learning and memory tasks, but after a stroke, they could no longer perform these tasks,” Dr Walker said.
“We found that learning and memory deficits of stroke affected mice returned to normal when they were given selenium supplements.”
Some caveats about selenium
Dr. Walker said the results opened a new therapeutic avenue to boost cognitive function in people who were unable to exercise due to poor health or old age.
“However, selenium supplements shouldn’t be seen as a complete substitute for exercise, and too much can be bad for you,” she said.
“A person who is getting a balanced diet of fruits, nuts, veggies and meat usually has good selenium levels.
“But in older people, particularly those with neurological conditions, selenium supplements could be beneficial,” she added.
SOURCE:
REFERENCE:
- Leiter, O., Zhuo, Z., Rust, R…Walker, T. Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging. Cell Metabolism, online February 3, 2022, DOI: 10.1016/j.cmet.2022.01.005
