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Kisunla Vs. Leqembi – The New Alzheimer’s Drugs

Leqembi and Kisunla
Two breakthrough drugs, Leqembi and Kisunla, are the first to actually slow down Alzheimer's. How do they compare to each other? (Video+Article)
Kisunla (Donanemab)
Kisunla
(Donanemab)
Leqembi (Lecanemab)
Leqembi
(Lecanemab)
Drug Class
Monoclonal antibody.
Binds itself to plaque AFTER
fibers have clumped together
as larger plaques in the brain.
Monoclonal antibody.
Lecanemab targets
amyloid-beta (Aβ) plaque
EARLIER on, as it forms fibers.
Approval
July 2, 2024
July 2023
Infusions
1 / month
2 / month
If scans show substantial
clearing of brain
Often OK to stop treatment
after 6 – 18 months
Continue treatment anyway
Cost
$32,000 / year
$26,000 / year
At 18 months,
improved cognitive decline
35%
30%
More Convenient Injectable Version
No
Expected mid-2025
Official # of Patients Treated
0
2,000
Cost to patient with Medicare
Part B, besides non-drug costs)
About 20%
(Around $6,400 / year)
About 20%
($5,300 /year)
Side Effects:
Adverse Events
17.4%
21.3%
ARIA (Amyloid-Related
Imaging Abnormalities)
37%
21%
Brain swelling
25%
12.6%

 

Kisunla vs. Leqembi: A Comparative Overview

Let’s compare Kisunla and Leqembi, two drugs used in the treatment of Alzheimer’s disease:

1. Drug Class:

      • Kisunla:
            • Belongs to a new class of drugs designed to slow the progression of Alzheimer’s disease.

            • A monoclonal antibody that targets beta-amyloid, the toxic protein that accumulates in the brains of Alzheimer’s patients, forming plaques that disrupt normal brain signaling.

        • Leqembi:
              • Also a monoclonal antibody targeting beta-amyloid.

              • Approved last year for certain patients with early Alzheimer’s disease.

        2. Approval:

          3. Effectiveness:

              • Kisunla:
                    • May slow declines in memory and thinking skills in early-stage Alzheimer’s patients.

                    • Cannot reverse memory loss or other symptoms.

                    • Not a cure.

                • Leqembi:
                      • Similar effects to Kisunla.

                4. Brain Scans:

                  Remember that neither drug can reverse existing brain damage, and benefits are modest. Consult your doctor to determine the best treatment for your specific situation. 🧠


                  Learn more:

                  1. alzinfo.org
                  2. pbs.org
                  3. apnews.com
                  4. biospace.com

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                  P. Berger

                  This site was inspired by my Mom’s autoimmune dementia.

                  It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. it has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

                  The site is dedicated to all those preserving the dignity of the community of people living with dementia.

                  Peter Berger, Editor

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                  This site was inspired by my Mom’s autoimmune dementia.

                  It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. it has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

                  The site is dedicated to all those preserving the dignity of the community of people living with dementia.

                  Peter Berger, Editor

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                  This site was inspired by my Mom’s autoimmune dementia.

                  It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. It has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

                  The site is dedicated to all those preserving the dignity of the community of people living with dementia.

                  Peter Berger, Editor

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