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The Bad & The Good in Statins & Alzheimer’s

Statins certainly seem to lower the risk of Alzheimer's. On the other hand, they can sometimes cause temporary memory loss, which does go away if one stops the statins. Find out what you need to know to strike the right balance.
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As with any medication, the more you know about statins, the more ability you have to help your doctor give you the best treatment possible.

THE BAD:
Statin-Associated Memory Loss

Doctors found that some patients to whom they precribed statins ended up reporting memory loss assoicated with the drug.

It certainly did not happen to everyone. In the study, Statin-associated memory loss: analysis of 60 case reports and review of the literature, patients reporting such memory loss were identified and observed. Other studies followed, including one in 2010 that reported 600 such cases linked to Lipitor.

Although there was a clear association, no one has been able to prove a cause-and-effect relationship. That is why doctors are careful to check for other reasons behind memory loss before they start cutting back the statins. Heart disease, age and even Alzheimer’s can be to blame.

Dementia-expert Dr. P. Murali Doraiswamy offers the following advice.

“Clearly, if lowering the dose made the problem better, then that suggests the statin was the cause. However, reducing the dose of a statin can raise risk for heart disease and stroke in some situations. I don’t recommend people stop or change dose of statins on their own, but to work through their doctors. This may also sometimes involve educating your doctors about the new risks associated with statins.”

THE GOOD:
High dose statins prevent dementia 

High doses of statins prevent dementia in older people, according to research presented at the ESC Congress by Dr. Tin-Tse Lin from Taiwan. The study of nearly 58,000 patients found that high potency statins had the strongest protective effects against dementia.

Dr. Lin said: “Statins are widely used in the older population to reduce the risk of cardiovascular disease. But recent reports of statin-associated cognitive impairment have led the US Food and Drug Administration (FDA) to list statin-induced cognitive changes, especially for the older population, in its safety communications.”

He added: “Previous studies had considered statin therapy to exert a beneficial effect on dementia. But few large-scale studies have focused on the impact of statins on new-onset, non-vascular dementia in the geriatric population.”

Accordingly, the current study examined whether statin use was associated with new diagnoses of dementia. The researchers used a random sample of 1 million patients covered by Taiwan’s National Health Insurance. From this they identified 57,669 patients aged >65 years who had no history of dementia in 1997 and 1998. The analysis included pre-senile and senile dementia but excluded vascular dementia.

There were 5,516 new diagnoses of dementia during approximately 4.5 years of follow-up. The remaining 52,153 patients aged >65 formed the control group. Subjects were divided into tertiles according to their mean daily equivalent1 dosage and total (across the entire follow up period) equivalent dosage.

The adjusted hazard ratios (HRs) for dementia were significantly inversely associated with increased daily or total equivalent statin dosage. The HRs for the three tertiles of mean equivalent daily dosage (lowest to highest) were 0.622, 0.697 and 0.419 vs control (p<0.001 for trend). The HRs for the three tertiles of total equivalent dosage (lowest to highest) were 0.773, 0.632 and 0.332 vs control (p<0.001 for trend). The protective effect of statins remained in different age, gender and cardiovascular risk subgroups.

Dr. Lin said: “The adjusted risks for dementia were significantly inversely associated with increased total or daily equivalent statin dosage. Patients who received the highest total equivalent doses of statins had a 3-fold decrease in the risk of developing dementia. Similar results were found with the daily equivalent statin dosage.”

He added: “It was the potency of the statins rather than their solubility (lipophilic or hydrophilic) which was a major determinant in reducing dementia. High potency statins such as atorvastatin and rosuvastatin showed a significant inverse association with developing dementia in a dose-response manner. Higher doses of high potency statins gave the strongest protective effects against dementia.”

Dr. Lin continued: “The results were consistent when analysing daily doses of different kinds of statins. Almost all the statins (except lovastatin) decreased the risk for new onset dementia when taken at higher daily doses. A high mean daily dosage of lovastatin was positively associated with the development of dementia, possibly because lovastatin is a lipophilic statin while the anti-inflammatory cholesterol lowering effect of lovastatin is not comparable to that of atorvastatin and simvastatin.”

Dr. Lin concluded: “To the best of our knowledge, this was the first large-scale, nation-wide study which examined the effect of different statins on new onset dementia (except vascular dementia) in an elderly population. We found that high doses of statins, particularly high potency statins, prevent dementia.”


SOURCES:

THE NEW YORK TIMES

THE EUROPEAN SOCIETY OF CARDIOLOGY
The European Society of Cardiology (ESC) represents more than 80 000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.

REFERENCE:
More information on the ESC Press Conference page: Statins for all forever?

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JKD53
JKD53
November 14, 2017 7:42 pm

Everything I have now read on this relationship between Lipitor and Dementia is textbook for what I have experienced this last TERRIBLE four years. Everything from forgetting my sister's death, my son's wedding, trip to the bottom of volcano in Hawaii. Regular as clockwork once a month another spell of memory loss. Doctors started on anxiety drugs, then depression drugs, then mode stabilizers, hypnosis you name it. Termed Transit Global Amnesia, except that supposedly only happens three or four times. Nine Doctors common answer,"I have never seen anything like this before. It is very strange."

Now my question I have stopped the lipitor, how long before I notice any change? Or will there be any change?

Unknown
Unknown
December 14, 2016 9:31 pm

Well it's all true unfortunately one size doesn't fit all ..in some cases for a period statins can be beneficial as is true for anti biotic..it's the mass prescribing that is criminal my cholesterol is between 11- 14 without them double dosage with them it is 5.5 family history of heart attacks and strokes mother died at 42 old Ellen lasted till 55 the rest died in their 30s except for 2… in short believe what you want ..I am up for a bypass quadruple so I am back on the statins ..but basically exercise and nutrition is what will save me not the stains or the bypass…death is scarey but this toxic life is a sham.. I do forget stuff I forget I am up for a by pass I forget I won't live forever..and I forget to be nice to ppl..

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P. Berger

This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. it has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

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This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. it has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

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This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. It has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

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