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Visualizing Alzheimer’s


See Dr. Anthony Fitzpatrick use world-class cryo-electron microscopes to reveal molecular secrets leading to a cure for Alzheimer’s.

Alzheimer’s plaque is caused by proteins that aggregate together. Protein aggregation is a hallmark of many neurodegenerative diseases such as Alzheimer’s. However, the mechanisms linking aggregation to Alzheimer’s neurotoxicity remain poorly understood.

One reason is because only limited information is available on the structure of these aggregates. Determining the atomic structures of these aggregates is crucial to understanding their formation, clearance and spread in the human brain. It makes sense that this even holds the important key to unlocking better Alzheimer’s treatments.

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Furthermore, very little is known about the native structure of protein aggregates inside cells. This challenge is addressed utilizing the latest developments in world-class microscopes using cryo-electron tomography (cryo-ET). Thin lamellas of vitrified cells containing protein aggregates are prepared by cryo-focused ion beam (cryo-FIB) and subsequently imaged in three dimensions by cryo-ET.

Cryo-Electron Microscopy is helping Dr. Anthony Fitzpatrick’s lab at Columbia University in New York to untangle amyloid fibrils isolated from post-mortem brain tissue of patients with Alzheimer’s and other types of dementia.

These super-high-powered microscopes elucidate the molecular and structural basis of neurodegeneration. Additionally, cryo-ET allows for the analysis of aggregate structures within pristinely preserved cellular environments at molecular resolution, shedding new light on the cellular mechanisms of neurodegeneration.

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B. Berger

B. Berger

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This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chaffe, the important articles & videos from each week’s river of news. With a new post on Alzheimer’s or dementia appearing on the internet every 7 minutes, the site’s focus on the best information has been a help to many over the past 15 years. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor


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