Share This Page

Support & Insight for the Autumn of Life

Clarifying Inflammation’s Role in Alzheimer’s

12.12.23-brai.png
Researchers have long connected inflammation & Alzheimer's. Find out how interleukin-1 beta clarifies that connection. Learn about the Alzheimer's treatment targets uncovered by this discovery. (Video+Article)

An international team of researchers from UMass Medical School, the University of Bonn and the Center for Advanced European Studies and Research in Germany have shown that an immune and inflammatory process already established as a clinical target for rheumatoid arthritis plays an important role in the pathology of Alzheimer’s disease, meaning drugs now used to target that process may benefit patients with Alzheimer’s.

This process results in the mature production of the pro-inflammatory cytokine called interleukin-1 beta (IL-1β) and is involved in the body’s defense against infection. The finding, published in Nature, points to the possibility that drugs that disrupt the production of IL-1β, such as those for rheumatoid arthritis, may also prove beneficial for patients with Alzheimer’s.

“This finding represents an important new clinical target for patients with Alzheimer’s disease,” said Douglas T. Golenbock, MD, professor of medicine and microbiology & physiological systems and chief of infectious diseases and immunology. “We’ve known for years that the plaques associated with Alzheimer’s were surrounded by microglia, the resident immune cell of the central nervous system. What we didn’t know was what role, if any, inflammation played in the progression of the disease. With this link we have a new path to potentially identifying and attacking this horrible disease.”

The most common form of dementia, Alzheimer’s is a degenerative neurological disorder that leads to memory loss, impaired cognitive function and eventually death. By 2050, it is predicted that one in 85 people will suffer from Alzheimer’s disease. There are no treatments available.

A key physiological component of Alzheimer’s disease is the presence of extracellular plaques, primarily composed of beta amyloid peptides, which aggregate in the brain. These plaques are believed to be toxic and the chief cause of nearby neuron death and cortical material loss. The hippocampus, which plays an important role in short-term memory, is one of the first regions of the brain to suffer damage from Alzheimer’s.

Dr. Golenbock and colleagues had established in previous studies that neurons in cell cultures died after nearby microglia cells, the main form of active immune defense in the brain and spinal cord, were exposed to amyloid beta fibrils, such as those found in Alzheimer’s plaques. Typically, microglias are responsible for removing plaques, damaged neurons and infectious agents from the central nervous system. The beta amyloid peptide, however, generates inflammation in the central nervous system by activating microglia to produce neurotoxic compounds, including cytokines. How this process was being activated in patients with Alzheimer’s disease, though, was unclear.

Earlier work done in the Golenbock laboratory demonstrated that beta amyloid peptide could induce the production of IL-1β by activating a multi-protein receptor complex in microglial cells known as the NLRP3 inflammasome. Because of its ability to sense the beta amyloid peptide, the NLRP3 inflammasome has been implicated in several chronic inflammatory diseases, including gout and asbestosis. Examining Alzheimer’s tissue samples, scientists found that “every one of the cell samples contained increased evidence of activated inflammasomes, strongly suggesting that they were producing IL-1β,” said Golenbock.

“Taken together with our earlier studies, this strongly suggested a role for NLRP3 and caspase-1 in producing IL-1β leading to Alzheimer’s disease progression,” Golenbock said.

To assess the precise impact of NLRP3 and caspase-1 on Alzheimer’s disease in an organism, researchers recorded cognitive function and memory in mice models that expressed genes associated with familial Alzheimer’s but that were deficient in NLRP3 or caspase-1, and compared them with Alzheimer’s mice that had otherwise intact immune systems. When researchers performed memory recall tests of the Alzheimer’s in NLRP3- or caspase-1-mutant mice, they found the animals exhibited far better memory recall and appeared protected from memory loss. However, Alzheimer’s mice that expressed NLRP3 and caspase-1 at normal levels exhibited symptoms consistent with Alzheimer’s disease. Further examination revealed that NLRP3 and caspase-1 deficient mice showed a decrease in beta amyloid plaques and in increased ability of the microglia to remove fibrillar beta amyloid from the brain.

It was also revealed that activated IL-1 levels in the NLRP3 and caspase-1 deficient mice were reduced compared to symptom-bearing counterparts. Because of NLRP3 and caspase-1 deficits, these mice produced less IL-1. These deficits appeared to promote formation of a microglia cell phenotype that was more capable of metabolizing and removing Alzheimer’s plaques from the central nervous system.

“These findings suggest that a knockout of NLRP3, caspase-1 or mature IL-1β may represent a novel therapeutic intervention for Alzheimer’s disease,” said Golenbock. “It’s possible that drugs that block NLRP3 or IL-1β—including some of which are already in clinical trials or on the market—might provide some benefit,” said Golenbock.

“The critical part, though, is how much NLRP3 or IL-1β production can these drugs disrupt,” said Golenbock. “I believe that it’s not enough to block just 90 percent; it will probably have to be closer to 100 percent.”

Email me when people comment
Notify of
guest

1 Comment
Inline Feedbacks
View all comments
Protirelin
Protirelin
October 20, 2016 9:51 am

Considerable evidence gained over the past decade has supported the conclusion that neuroinflammation is associated with Alzheimer's disease (AD) pathology. Inflammatory components related to AD neuroinflammation include brain cells such as microglia and astrocytes.

Edited by:
Picture of P. Berger

P. Berger

This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. it has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

Share this page To

Related:

Share to Facebook
Twitter
LinkedIn

This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. it has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

Visit Alzheimer's Weekly On

1
0
Would love your thoughts, please comment.x
()
x
News, Treatments, Care Tips, Diet

Alzheimer's & Dementia Weekly Newsletter
Free

This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. It has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

Care & Treatment. Research & Prevention
News to Get at the Truth

Subscribe To Our Weekly Newsletter