Share This Page

Support & Insight for the Autumn of Life

Lecanemab Enters Advanced Alzheimer’s Gene Trials

VIDEO + ARTICLE:

Phase II/III trials are begining in the Tau NextGen study. The study will assess the effect of Lecanemab, an experimental anti-amyloid therapy, in pre-symptomatic or symptomatic participants who have an Alzheimer’s-causing gene mutation. Learn more.


The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), led by Washington University School of Medicine in St. Louis, has enrolled the first subject in the Phase II/III study (Tau NexGen study). The DIAN is an international research effort focused on dominantly inherited Alzheimer’s disease.

The study will assess the effect of Eisai’s investigational anti-microtubule binding region (MTBR) tau antibody E2814, in dominantly inherited Alzheimer’s disease (DIAD).

What this study examines

People who have genetic mutations of DIAD, a rare form of Alzheimer’s disease (AD) that causes memory loss and dementia, are likely to develop symptoms at around the same age their affected parents did, often in their 50s, 40s or even 30s.

The major AD pathologies are amyloid plaque that consists of amyloid beta (Aβ) aggregates; neurofibrillary tangles; and intraneuronal aggregates of tau, all of which are believed to spread throughout the brain.

The purpose of the Tau NexGen (New Window) study is to assess the safety, tolerability, biomarker and cognitive efficacy of investigational therapies in pre-symptomatic or symptomatic participants who have an AD-causing gene mutation.

Lecanemab targets amyloid

The Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) is an international public-private partnership dedicated to designing and managing interventional therapeutic trials for individuals with and at risk of DIAD. The DIAN-TU is dedicated to finding solutions to treat or prevent this disease and, potentially, all forms of Alzheimer’s.

In March 2021, the DIAN-TU selected E2814, which was created from a research collaboration between Eisai and University College London, as the first investigational medicine among anti-tau drugs for the Tau NexGen study.

With increasing evidence from clinical studies showing that targeting amyloid can reduce biomarkers of Alzheimer’s disease, the Tau NexGen(New Window) clinical trial leaders then selected Eisai’s investigational anti-Aβ protofibril antibody lecanemab (BAN2401) as the background anti-amyloid therapy, and the study design was amended in November 2021.

SOURCE:

Email me when people comment
Notify of
guest

This site uses Akismet to reduce spam. Learn how your comment data is processed.

0 Comments
Inline Feedbacks
View all comments
Edited by:
Picture of P. Berger

P. Berger

This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. it has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

Share this page To

Related:

Caregiving

Virtual Dementia Tour’s Patent

VIDEO & ARTICLE: 500,000 family and professional caregivers have experienced The Virtual Dementia Tour®. It simulates Alzheimer’s for caregivers. It boosts their level of care

Read More »
Diet

Can Alzheimer’s Be Treated with Iron-Modifying Drugs?

Dietary iron is an essential element in the brain. That’s why it is critical to understand how it affects Alzheimer’s. Researchers used advanced X-ray techniques to take a giant step forward in understanding iron chemistry in amyloid plaque, the main culprit behind Alzheimer’s. Learn more about their exciting new insights.

Read More »
Share to Facebook
Twitter
LinkedIn

This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. it has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

Visit Alzheimer's Weekly On

0
Would love your thoughts, please comment.x
()
x
News, Treatments, Care Tips, Diet

Alzheimer's & Dementia Weekly Newsletter: Free

Free. Care & Treatment. Research & Prevention

This site was inspired by my Mom’s autoimmune dementia.

It is a place where we separate out the wheat from the chafe, the important articles & videos from each week’s river of news. Google gets a new post on Alzheimer’s or dementia every 7 minutes. That can overwhelm anyone looking for help. This site filters out, focuses on and offers only the best information. It has helped hundreds of thousands of people since it debuted in 2007. Thanks to our many subscribers for your supportive feedback.

The site is dedicated to all those preserving the dignity of the community of people living with dementia.

Peter Berger, Editor

News to Get at the Truth

Subscribe To Our Weekly Newsletter